科研
723 个结果
- Protein Binder DesignK-DenseDesign new proteins that bind a chosen surface, using BindCraft's AlphaFold2-guided hallucination or the RFdiffusion backbone plus ProteinMPNN sequence pipeline. Use this skill to specify a target epitope by hotspot residue, trim a receptor to the region worth designing against, set up a design campaign, and filter the output on the in-silico metrics that predict experimental success — interface…
- PytdcK-DenseUse Therapeutics Data Commons through the PyTDC Python package for registry discovery, approved dataset access, task-aware splits (scaffold, cold-start, temporal, combination), evaluator metrics, benchmark groups, and bounded molecular-oracle workflows.
- RdkitK-DenseCheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and…
- RetrosynthesisK-DensePlan synthetic routes and judge whether a proposed molecule can actually be made, using AiZynthFinder's Monte-Carlo tree search over template-derived reactions and a purchasable building-block stock. Use this skill to configure expansion and filter policies, choose a stock file, run route search over a candidate set, and read the returned trees — solved fraction, route depth, and which building…
- Target SafetyK-DenseAssemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and…
- Uniprot RcsbK-DenseRetrieve protein sequences, annotation, and structures from UniProtKB, the RCSB PDB, and AlphaFold DB. Use this skill to resolve a gene or protein name to a UniProt accession, pull sequences and FASTA files, find binding sites and domains, search the PDB by UniProt accession, sequence, ligand, or text, download mmCIF/PDB coordinates and biological assemblies, fetch AlphaFold models with their…
- SearchTinyFishDefault, free web search that returns compact, structured results, faster and more token-efficient than built-in search. Search the web for current information, news articles, or research papers, with recency filters (past N minutes, before/after date windows), location, language, and include/exclude domain filters.
- Arxiv SearchDeevsDeevsSearch arXiv preprint repository for research papers in physics, mathematics, computer science, quantitative biology, finance, and statistics. Use when finding academic papers, preprints, ML research, scientific publications. Triggers: arxiv, preprint, research paper, academic paper, scientific literature.
- ElnjkitchinProfessional scientific documentation in org-mode electronic lab notebooks with date-based organization, comprehensive record-keeping of hypotheses, methods, results, reasoning, and outcomes for reproducible research
- FairchemjkitchinExpert guidance for Meta's FAIRChem library - machine learning methods for materials science and quantum chemistry using pretrained UMA models with ASE integration for fast, accurate predictions
- Materials PropertiesjkitchinExpert assistant for calculating materials properties from first-principles using ASE - structure relaxation, surface energies, adsorption, reaction barriers, phonons, elastic constants, and thermodynamic modeling with proper scientific methodology
- PymatgenjkitchinComprehensive guidance for using pymatgen (Python Materials Genomics) for computational materials science. Covers structure creation and manipulation, file I/O (CIF, POSCAR, XYZ), symmetry analysis, Materials Project API integration, phase diagrams, electronic structure analysis, and DFT input generation.
- Msw Defaultplayermsw-gitMSW DefaultPlayer (character) management. Use the msw-general ModelBuilder to inspect/patch DefaultPlayer.model and Player.model, add/remove components, configure movement speed / jump force / HP / camera, and per-map-mode movement components. Use for DefaultPlayer model, player components, movement speed, jump force, HP, camera, physics.
- Phaser GamedevchongdashuBuild 2D games with Phaser 3 framework. Covers scene lifecycle, sprites, physics (Arcade/Matter), tilemaps, animations, input handling, and game architecture. Trigger: "create phaser game", "add phaser scene", "phaser sprite", "phaser physics", "game development with phaser".
- Clinical Nlp ExtractormdbabumiamssmExtracts medical entities (Diseases, Medications, Procedures) from unstructured clinical text using regex and simple rules (or LLM wrappers).
- Medical ResearchgexijinRetrieves scientific papers from PubMed and creates plain-language research summaries. Use when users ask about medical research, scientific studies, clinical trials, disease treatments, or want to understand recent scientific literature on any biomedical topic.
- Humanize ChineseSway Liu中文去 AI 腔一整套（装完即用，零 API Key —— 装了本 skill 的 agent 自己就是那个 LLM）。 六个流程：① 生成即去 AI —— 写中文时按本 skill 的写作指南落笔，初稿就不带 AI 腔； ② 复查改写 —— 产出后对照本 skill 的清单再过一遍，定点拆模板句式； ③ Python 词语替换 —— ./humanize replace 按文体自动路由词表（学术 120+ 条 / 通用 220+ 条），只做短语级、只在子句边界替换，改完自动核对数字/专名/段落； ④ Claude 腔转中文 —— 把 Claude 助手腔的中文改写成平实中文， 规则提炼自 gvzdv/claudish-to-english 并本地化； ⑤ 去水印 —— ./humanize watermark 扫清零宽字符/双向控制符/同形替身， 并对照…
- Xarray For Multidimensional Datauw-ssecWork with labeled multidimensional arrays for scientific data analysis using Xarray. Use when handling climate data, satellite imagery, oceanographic data, or any multidimensional datasets with coordinates and metadata. Ideal for NetCDF/HDF5 files, time series analysis, and large datasets requiring lazy loading with Dask.
- Physics TutorszeyuPhysics subject expertise for study notes, problem-solving, and explanations. Covers mechanics, electromagnetism, thermodynamics, waves, and modern physics. Provides diagrams, formulas, and step-by-step problem solutions. Use when studying physics topics, creating physics notes, solving physics problems, or explaining physical concepts.
- Bioinformatics God Skillzwbao生物信息学之神——综合50位顶级学者的思维框架。基于970行著作调研、389行对话分析、 297行表达DNA、133行外部批评、529行关键决策、320行时间线的深度调研， 提炼7个核心心智模型、10条决策启发式、6大学派张力和完整的学科表达DNA。 用途：作为生物信息学全域思维顾问，用领域最高水平的视角分析问题、审视方法、评估工具。 当用户提到「用生物信息学之神的视角」「bioinformatics god」「生信之神怎么看」时使用。 即使用户只是说「帮我从生信的最高视角分析这个」「如果生物信息学顶级专家会怎么看」也应触发。
- ChemdrawZiChenWang114514Use ChemDraw and cdxml-toolkit for editable chemical structures, reaction figures, ACS Document 1996 drawings for exams and papers, image reconstruction, scientific drawings, chemical analysis, and ChemDraw objects in Office; also install or diagnose their runtime.
- Nianozomio-labsIndex and search code repositories, documentation, research papers, HuggingFace datasets, local folders, Slack workspaces, Google Drive, X (Twitter), and packages with Nia AI. Includes auth bootstrapping, Oracle autonomous research, GitHub live search, Tracer agent, dependency analysis, context sharing, code advisor, document agent, data extraction, filesystem operations, and generic connectors.
- Math Modeling SkillLEEHAHAHAHA数学建模竞赛(国赛/美赛/校赛/企业赛/研究生赛)从读题到论文交付的标准化全流程能力——读题拆解、方案选择(大道至简+多候选)、模型搭建(机理优先/可解释)、代码实现(防伪数据/Search-Replace 纠错/可复现)、可视化风格(三套学术配色+八大绘图类型选择指南+宋体Times 字体+TikZ 流程图+论文总体架构图+详细图片命名)、论文写作(各部分长度/降 AI 率/不堆砌/公式数量合适/图表就近/图表说明100–150字/单页图表占比≤2/3禁图挨图/正文页数21–30)、审稿与修改(九维评审+三级问题清单+修复循环+评分+版面逐页视觉审查+乱码复检)。
- Research Schematic DesignHan HuCreate publication-quality, editable scientific and engineering schematics with explicit physical meaning, exact labels, visual hierarchy, and provenance. Use for experimental facilities, thermal-fluid mechanisms, workflows, graphical abstracts, system architectures, or research diagrams.