Store and query genomic variant data at scale with TileDB-VCF — ingest VCF/BCF into compressed TileDB arrays, add samples incrementally, run fast parallel region/sample queries, and export back to VCF. Use when managing population-genomics variant datasets that are too large for flat VCF, building joint variant stores, or querying thousands of samples by region.
Install
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-tiledbvcfnpx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-tiledbvcf -a claude-code -gnpx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-tiledbvcf -a codex -ggemini skills install https://github.com/AlterLab-IEU/AlterLab-Academic-Skills.git --path skills/bioinformatics/alterlab-tiledbvcfgh skill install AlterLab-IEU/AlterLab-Academic-Skills alterlab-tiledbvcfgit clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills /tmp/AlterLab-IEU__AlterLab-Academic-Skills
mkdir -p ~/.claude/skills ~/.agents/skills
cp -R /tmp/AlterLab-IEU__AlterLab-Academic-Skills/skills/bioinformatics/alterlab-tiledbvcf ~/.claude/skills/alterlab-tiledbvcf # Claude Code
cp -R /tmp/AlterLab-IEU__AlterLab-Academic-Skills/skills/bioinformatics/alterlab-tiledbvcf ~/.agents/skills/alterlab-tiledbvcf # Codex, Cursor, Gemini CLI, Copilot, OpenCode