This skill performs differential DNA methylation analysis (DMRs and DMCs) between experimental conditions using WGBS methylation tracks (BED/BedGraph). It standardizes input files into per-sample four-column Metilene tables, constructs a merged methylation matrix, runs Metilene for DMR detection, filters the results, and generates quick visualizations.
Install
npx skills add BIsnake2001/ChromSkills --skill differential-methylationnpx skills add BIsnake2001/ChromSkills --skill differential-methylation -a claude-code -gnpx skills add BIsnake2001/ChromSkills --skill differential-methylation -a codex -ggemini skills install https://github.com/BIsnake2001/ChromSkills.git --path 21.differential-methylationgh skill install BIsnake2001/ChromSkills differential-methylationgit clone --depth 1 https://github.com/BIsnake2001/ChromSkills /tmp/BIsnake2001__ChromSkills
mkdir -p ~/.claude/skills ~/.agents/skills
cp -R /tmp/BIsnake2001__ChromSkills/21.differential-methylation ~/.claude/skills/differential-methylation # Claude Code
cp -R /tmp/BIsnake2001__ChromSkills/21.differential-methylation ~/.agents/skills/differential-methylation # Codex, Cursor, Gemini CLI, Copilot, OpenCode