Design small interfering RNA and antisense oligonucleotide sequences against a transcript, and screen them for the failure modes specific to nucleic-acid drugs. Use this skill to tile a target transcript, apply positional and thermodynamic selection rules including duplex asymmetry and nearest-neighbour melting temperature, scan candidates for seed-region complementarity to off-target…
Install
npx skills add K-Dense-AI/drug-discovery-agent-skills --skill oligonucleotidesnpx skills add K-Dense-AI/drug-discovery-agent-skills --skill oligonucleotides -a claude-code -gnpx skills add K-Dense-AI/drug-discovery-agent-skills --skill oligonucleotides -a codex -ggemini skills install https://github.com/K-Dense-AI/drug-discovery-agent-skills.git --path skills/oligonucleotidesgh skill install K-Dense-AI/drug-discovery-agent-skills oligonucleotidesgit clone --depth 1 https://github.com/K-Dense-AI/drug-discovery-agent-skills /tmp/K-Dense-AI__drug-discovery-agent-skills
mkdir -p ~/.claude/skills ~/.agents/skills
cp -R /tmp/K-Dense-AI__drug-discovery-agent-skills/skills/oligonucleotides ~/.claude/skills/oligonucleotides # Claude Code
cp -R /tmp/K-Dense-AI__drug-discovery-agent-skills/skills/oligonucleotides ~/.agents/skills/oligonucleotides # Codex, Cursor, Gemini CLI, Copilot, OpenCode