Performs genomic interval overlap, nearest, merge, coverage, complement and subtraction on Polars DataFrames, and reads or writes BED, VCF, BCF, BAM, CRAM, GFF, GTF, FASTA and FASTQ data. Use for coordinate-aware genomic joins, read-depth analysis, lazy bioinformatics I/O, SQL queries or migration from bioframe.
Install
npx skills add K-Dense-AI/scientific-agent-skills --skill polars-bionpx skills add K-Dense-AI/scientific-agent-skills --skill polars-bio -a claude-code -gnpx skills add K-Dense-AI/scientific-agent-skills --skill polars-bio -a codex -ggemini skills install https://github.com/K-Dense-AI/scientific-agent-skills.git --path skills/polars-biogh skill install K-Dense-AI/scientific-agent-skills polars-biogit clone --depth 1 https://github.com/K-Dense-AI/scientific-agent-skills /tmp/K-Dense-AI__scientific-agent-skills
mkdir -p ~/.claude/skills ~/.agents/skills
cp -R /tmp/K-Dense-AI__scientific-agent-skills/skills/polars-bio ~/.claude/skills/polars-bio # Claude Code
cp -R /tmp/K-Dense-AI__scientific-agent-skills/skills/polars-bio ~/.agents/skills/polars-bio # Codex, Cursor, Gemini CLI, Copilot, OpenCode