This pipeline performs genome-wide segmentation of CpG methylation profiles to identify Unmethylated Regions (UMRs), Low-Methylated Regions (LMRs), and Partially Methylated Domains (PMDs) using whole-genome bisulfite sequencing (WGBS) methylation calls.
Install
npx skills add BIsnake2001/ChromSkills --skill UMR-LMR-PMD-detectionnpx skills add BIsnake2001/ChromSkills --skill UMR-LMR-PMD-detection -a claude-code -gnpx skills add BIsnake2001/ChromSkills --skill UMR-LMR-PMD-detection -a codex -ggemini skills install https://github.com/BIsnake2001/ChromSkills.git --path 26.UMR-LMR-PMD-detectiongh skill install BIsnake2001/ChromSkills UMR-LMR-PMD-detectiongit clone --depth 1 https://github.com/BIsnake2001/ChromSkills /tmp/BIsnake2001__ChromSkills
mkdir -p ~/.claude/skills ~/.agents/skills
cp -R /tmp/BIsnake2001__ChromSkills/26.UMR-LMR-PMD-detection ~/.claude/skills/UMR-LMR-PMD-detection # Claude Code
cp -R /tmp/BIsnake2001__ChromSkills/26.UMR-LMR-PMD-detection ~/.agents/skills/UMR-LMR-PMD-detection # Codex, Cursor, Gemini CLI, Copilot, OpenCode