Design protein sequences around bound ligands, metals, and nucleic acids with LigandMPNN (Dauparas 2023) — inverse folding that conditions on non-protein context, so binding-pocket and metal-site residues are chosen to fit the actual ligand.
安装
npx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-ligandmpnnnpx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-ligandmpnn -a claude-code -gnpx skills add AlterLab-IEU/AlterLab-Academic-Skills --skill alterlab-ligandmpnn -a codex -ggemini skills install https://github.com/AlterLab-IEU/AlterLab-Academic-Skills.git --path skills/bioinformatics/alterlab-ligandmpnngh skill install AlterLab-IEU/AlterLab-Academic-Skills alterlab-ligandmpnngit clone --depth 1 https://github.com/AlterLab-IEU/AlterLab-Academic-Skills /tmp/AlterLab-IEU__AlterLab-Academic-Skills
mkdir -p ~/.claude/skills ~/.agents/skills
cp -R /tmp/AlterLab-IEU__AlterLab-Academic-Skills/skills/bioinformatics/alterlab-ligandmpnn ~/.claude/skills/alterlab-ligandmpnn # Claude Code
cp -R /tmp/AlterLab-IEU__AlterLab-Academic-Skills/skills/bioinformatics/alterlab-ligandmpnn ~/.agents/skills/alterlab-ligandmpnn # Codex, Cursor, Gemini CLI, Copilot, OpenCode